Endocrine Abstracts

Background: Papillary thyroid carcinomas are the most common thyroid malignancies. They are more prevalent in women and have a bimodal age distribution. Thyroglossal duct cyst carcinomas are extremely rare (occurring in only 1% of all thyroglossal duct cysts). The large majority of these carcinomas are of thyroid origin.Case presentation: A 25-year-old woman with no significant medical history was referred to the Endocrinologist with 1-month complaints o...

Introduction and objectives: Anaplastic thyroid cancer (ATC) has a very low overall survival (OS) and progression free survival (PFS) due to fast growth and resistance to non-target therapies. A recent phase II study showed a dramatic increase in OS and PFS of BRAF V600E mutated ATC patients treated with Dabrafenib and Trametinib (DT). However as commonly reported in melanoma durable responses in ATC may be compromised by resistance mechanisms. Until now only a few ca...

Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...

Introduction: The prevalence of palpable thyroid nodules in Graves’ disease (GD) is approximately 15%. Cytopathologic interpretation in GD is challenging due to frequent cytomorphologic changes, namely after radioactive iodine (RAI) therapy. Some of the few published studies regarding fine-needle aspiration (FNA) in patients with GD, suggest an increased risk of malignancy of thyroid nodules arising in GD patients. However, the results are inconsistent, and there is no co...

Introduction: Breast cancer is the second most common neoplasm in women. Hormonal replacement therapy and combined hormonal contraception are established extrinsic hormonal risk factors for breast cancer. Therefore, the increase in the prevalence of infertility and the use of assisted conception techniques have raised questions regarding the potential risk of hormone-dependent neoplasms. We report the case of a woman diagnosed with bilateral metastasized breast cancer soon aft...

Endocrine disrupting chemicals (EDCs) are environmental chemicals/toxicants that humans and wildlife are exposed to and which interfere with the action of hormones. Bisphenol A (BPA) is classified as an EDC with xenoestrogenic activity and is recognized by the WHO as a chemical with potentially potent effects on humans throughout different phases of development. A significant knowledge gap still exists regarding the complete spectrum of BPA-induced effects on human physiology,...

Objective: Describe clinical, laboratorial, imaging features, therapeutic management and the outcomes of patients with clinically non-functioning pituitary adenomas (NFPAs) presenting at our department.Methods: Retrospective review of electronic medical records of all patients with NFPAs evaluated at our department between 2010 and 2019.Results: We evaluated 160 patients, 51.3% female, with a median age of 56.6 years (18–89). ...

Background: Pheochromocytoma is a rare catecholamine secreting tumor originating usually from adrenal medulla and representing approximately 5% of adrenal incidentalomas. Currently 10% of all pheochromocytomas are discovered incidentally during imaging studies for unrelated disorders.Case presentation: A thirty five year old woman with no relevant medical history presented at the emergency department with symptoms of left flank pain and vomiting. Abdomin...

Introduction: Type 2 diabetes (T2D) is a heterogeneous disease for which causal mechanisms are incompletely understood and subclassification may improve patient management. In the latest assessment of patients with adult-onset diabetes, Ahlqvist and colleagues (2018) defined five new subgroups: an autoimmune form, two severe forms (insulin-deficient and insulin-resistant diabetes) and two mild forms (obesity and age-related diabetes).Objectives:...

Introduction: The aging population brought new challenges in several diseases. Pituitary tumors are usually not related with elderly, although the rise in life expectancy has allowed its diagnosis in unusual age groups.Aim: To describe the pituitary tumors diagnosed in patients with age ≥ 80 yearsMethods: Retrospective observational study which included 23 patients with pituitary tumors with age ≥ 80 years observed in c...